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cmpA [2018-06-07 18:47:37]
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cmpA [2018-06-07 18:47:37]

cortex morphogenic protein A, checkpoint protein, orchestrates spore coat and cortex morphogenesis
locus
G8J2-20
pI
0.00
mw
4.00 kDa
function
represses cortex assembly until the successful initiation of spore coat assembly
product
cortex morphogenic protein A, adapter protein targeting SpoIVA for degradation by ClpXP upon spore envelope defects
synonyms

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.1|Spore coat proteins] → [category|SW 4.2.1.1.8|Not yet assigned]
  • Gene

    Coordinates
    525,021 → 528,076

    Phenotypes of a mutant

  • quicker progressing through the [SW|sporulation ] cycle [Pubmed|22463703]
  • overexpression of CmpA results in heat-sensitive sporulation [Pubmed|22463703,26387458], this can be suppressed by mutations in ''[gene|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|clpP]'' and ''[gene|297F53DAD3351E0C55108DD2C93B78FFB174438C|clpX]'' [Pubmed|26387458]
  • Protein

    Catalyzed reaction/ biological activity

  • orchestrates spore coat and cortex assembly [Pubmed|22463703]
  • represses cortex assembly until spore coat assembly successfully initiates [Pubmed|22463703]
  • [SW|Localization]

  • surface of the developing spore, this depends on a functional [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] [Pubmed|22463703,26387458]
  • [SW|Interactions]

  • [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|ClpX]-[protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|CmpA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|ClpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|ClpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA]) [Pubmed|26387458]
  • [protein|85DE3CB6CDA61C141C6030367C0A13BB642160B9|CmpA]-[protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA] (for [protein|297F53DAD3351E0C55108DD2C93B78FFB174438C|ClpX]-[protein|CB06A70DE7462CEB7AF5D8C28943C878DD56DE1A|ClpP]-dependent degradation of [protein|A25C1530DA7BB007A288E525404E9F775E219FE8|SpoIVA]) [Pubmed|26387458]
  • Expression and Regulation

    Operons

    genes
    [gene|85DE3CB6CDA61C141C6030367C0A13BB642160B9|cmpA]
    description
    [Pubmed|22463703,20709900]

    sigma factors

  • [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE]: sigma factor, [Pubmed|22463703], in [regulon|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE regulon]
  • regulatory mechanism

  • [protein|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID]: activation, [Pubmed|22463703], in [regulon|90DCE4F286D2C151D8BDBF0E024E6BBEC94E2397|SpoIIID regulon]
  • regulation

  • expressed in mother cell during [SW|sporulation ] ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|22463703]
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    References

    Reviews

  • 27227299,26418292,28408070
  • Original publications

  • 22463703,26387458,20709900